Abstract
Summary: Exposure of circulating rabbit granulocytes to the chemoat-tractant N-formyl-methionyl-leucyl-phenylalanine (FMLP) in vivo results in transient granulocytopenia, hypotension, and car-diorespiratory distress. The effectiveness of vitamin E in attenuating these responses was tested. Vitamin E accelerated the rate of return of granulocytes to the peripheral circulation after FMLP-induced granulocytopeniaand mitigated the hypotension. The reversible adherence of FMLP-stimulated granulocytes to endothelium offers a plausible mechanism to explain the transient granulocytopenia. From in vitro studies it was found that FMLP-activated granulocytes from animals treated with vitamin E showed decreased adherence to cultivated aortic endothelial monolayers when compared with FMLP-activated granulocytes from control animals.
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Lafuze, J., Weisman, S., Alpert, L. et al. Vitamin E Attenuates the Effects of FMLP on Rabbit Circulating Granulocytes. Pediatr Res 18, 536–540 (1984). https://doi.org/10.1203/00006450-198406000-00011
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DOI: https://doi.org/10.1203/00006450-198406000-00011