Abstract
It is not known whether recovery from HMD begins in spite of a deficiency of SAM or only after return to some critical value. Eight of 12 M. nemestrina primates delivered at 80% of normal gestation developed HMD and were sacrificed at defined stages in their recovery. Postmortem deflation stability (%total lung capacity [TLC] at P=10cm H2O pressure) and diphosphatidylcholine (DPC) quantities in unlavaged lung tissue and in bronchoalveolar lavage were compared to controls as well as four healthy term 3-4 week old infants.
We conclude that 1) the disparity between tissue and lavage DPC quantities in animals with HMD suggests a problem in release of SAM rather than tissue production and 2) clinical recovery and improvement in deflation stability occur despite DPC levels that are quite low compared to control but similar to older infants. (1Supported by NIH#HL19187 and #RR00166, 2Fellow of American Lung Association)
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Jackson, J., Palmer, S., Standaert, T. et al. SURFACE ACTIVE MATERIAL (SAM) COMPLIANCE CHANGES DURING REACOVERY FROM EXPERMENTAL HYALINE MEMBRANE DISEASE (HMD). Pediatr Res 18 (Suppl 4), 394 (1984). https://doi.org/10.1203/00006450-198404001-01805
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DOI: https://doi.org/10.1203/00006450-198404001-01805