Abstract
Hypercarbia (HC) induced increases in regional brain blood flow (RBBF) may augment regional brain bilirubin deposition (RBBD) in piglets (P). 10 2-4 day old P were infused with bilirubin (BR) to raise & maintain a serum BR of approximately 8 mg/dl. HC (pCO2=76mmHg) was induced with 15% CO2. 14 control (C) P had similar BR levels without HC. Serum free bilirubin was similar in C & HC P. RBBF (by microspheres) & RBBD were as follows:
(MĀ±SEM) *p<0.05 vs C, +p<0.05 vs CE value within HC group, CE-cerebrum,TH-thalamus,MB-midbrain,CB-cerebellum,BS-brainstem
RBBF was elevated in all regions during HC; the increases in the TH, MB & BS, were greater than for the CE. RBBD was increased following HC in MB & CB; and the increases in MB, CB, & BS were higher than for CE. Regional brain albumin deposition (125I-albumin) was similar in all brain regions. We conclude that deposition of unbound bilirubin in some brain regions is blood flow dependent.
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Burgess, G., Oh, W., Bratlid, D. et al. CEREBRAL HYPERPERFUSION AUGMENTS BRAIN BILIRUBIN DEPOSITION IN PIGLETS. Pediatr Res 18 (Suppl 4), 337 (1984). https://doi.org/10.1203/00006450-198404001-01467
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DOI: https://doi.org/10.1203/00006450-198404001-01467