Abstract
We have previously shown that HC results in spontaneous elevations of MABP and pressure passive increases in brain blood flow (BBF) in the newborn piglet. We further analyzed the mechanism of this phenomena by correlating these changes with acid base and plasma E data in 20 awake newborn piglets where HC (PaCO2:50-60 mmHg) was induced by breathing 15% CO2. During HC, E, MABP, and BBF increased significantly (p<0.05). The increase in MABP was directly related to E (r=.71 p<0.001). However, both E and MABP also demonstrated a significant correlation with the decrease in arterial blood pH (pH vs E:r=-.91, p<0.001; pH vs MABP:r=-.84 p<0.001) and the increase in base deficit (BD) (BD vs E:r=0.83, p<0.001), BD vs MABP:r=0.84 p<0.001). PaCO2 was not related to the E or MABP increase. The increase in total BBF (TBBF) and regional BBF were directly related to the elevations of MABP (TBBF:r=0.58 p<0.01 cerebrum r=0.57 p<0.01, cerebellum:r=0.67 p<0.01, boundary zone r=0.62 p<0.01 and periventricular area r=.76 p<0.001). We conclude that HC induced hypertension and brain hyperperfusion is partly due to catecholamine (epineprine) release which in turn is mediated through concurrent metabolic acidosis.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brubakk, AM., Bratlid, D., Oh, W. et al. CHANGES IN EPINEPHRINE (E) AND MEAN ARTERIAL BLOOD PRESSURE (MABP) DURING HYPERCARBIA (HC): EFFECTS ON BRAIN BLOOD FLOW (BBF) IN THE NEWBORN PIGLET. Pediatr Res 18 (Suppl 4), 337 (1984). https://doi.org/10.1203/00006450-198404001-01466
Issue Date:
DOI: https://doi.org/10.1203/00006450-198404001-01466