Abstract
Leukotrienes (L) have been implicated in the pathogenesis of HPH in adult animals. Elevated (L) levels have also been noted in neonates with persistent pulmonary hypertension. We studied the hemodynamic effects of FPL 57231 in HPH induced in 9 piglets by ventilation with 12% 02. Cardiac index (CI), pulmonary artery (Ppa), systemic arterial (AoP), pulmonary wedge and right atrial pressures were measured, and pulmonary (PVR) and systemic vascular (SVR) resistances and their ratio (PVR/SVR) calculated prior to and after hypoxia (H). These parameters were compared during continued hypoxia between a control group (C) (n,4;wt,3596±1284g; age 17±10 days) and a treatment group (T) (n,5;wt,2958±1130g;age 14±5 days) which received FPL 57231 (2 mg/kg/min × 10 min). Patterns of response were compared by ANOVA.
AoP was similar between groups. The decrease in PVR and Ppa after FPL 57231 suggest that (L) may in part mediate HPH in piglets. In addition, these effects can be ameliorated by FPL 57231 without significant vascular effects.
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Goldberg, R., Ahmed, T., Suguihara, C. et al. THE EFFECTS OF LEUKOTRIENE ANTAGONIST FPL 57231 ON HYPOXIC PULMONARY HYPERTENSION (HPH) IN PIGLETS. Pediatr Res 18 (Suppl 4), 323 (1984). https://doi.org/10.1203/00006450-198404001-01383
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DOI: https://doi.org/10.1203/00006450-198404001-01383