Abstract
The occurrence of thrombocytopenia and disseminated intra-vascular coagulation (DIC) are newborn hematologic manifestations of maternal hypertension syndromes. Since hepatic disease occurs in mothers with preeclampsia-eclampsia we examined the levels of various coagulation factors to determine if other coagulopathies exist other than DIC. Fifty-three (53) cord blood samples were studied (PTT; pro time; fibrinogen, factors II, V, VII, VIII, IX, X, XII levels). There were 30 normal term controls, 6 with pregnancy-induced hypertension (PIH) and 17 with moderate to severe preeclampsia (PRE). Newborns with asphyxia were excluded. The mean gestational age was 37 in the two study groups; APGARs were 8/9 in PIH and 7/8 in PRE. The significant changes (*) are shown in the Table (mean ±SE).
Reduced factor VII and V with elevated factor VIII levels in the PRE group suggest liver damage as the cause of the coagulopathy. Elevated factor VIII levels was the only abnormality found in PIH neonates. No infant had DIC or evidence of vitamin K deficiency. Hepatic dysfunction may be a major manifestation of infants born of toxemic mothers.
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Lox, C., Word, R., Jeter, M. et al. CORD BLOOD COAGULATION CHANGES IN MATERNAL HYPERTENSIGN. Pediatr Res 18 (Suppl 4), 317 (1984). https://doi.org/10.1203/00006450-198404001-01343
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DOI: https://doi.org/10.1203/00006450-198404001-01343