Abstract
During a 29-month period, we studied enteric infection in 70 families (134 children, 136 adults) from a pediatric practice in suburban Washington. The subjects represent a cohort followed longitudinally. FAd were detected in stools of 18 patients and studied by at least one of three methods: 1) culture, electron microscopy or immune electron microscopy plus neutralization, 2) restriction endonuclease analysis, or 3) hybridot probe. During the 2nd year of life, 10 of every 100 individuals had gastrointestinal (GI) illness temporally associated with the presence of FAd. Only three of the FAd identified in children with diarrhea were enteral adenoviruses (EAd). They were group G by restriction endonuclease analyses (EcoRI, KpnI). In children 6-23 months of age, the incidence of FAd associated with enteritis was 4-10 per 100 per year; with confirmed EAd infection, 2-3 per 100 per year. All patients with EAd had diarrhea, but none required hospitalization. Those who excreted EAd had vomiting (66%), diarrhea (100%) and fever (33%). None of 9 contacts (6 adults, 3 children) of those who had EAd enteritis shed adenovirus in stool. In contrast, within the same family groups, rotavirus spread readily to adults (16/65, 25%) and children (36/62, 56%).
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Rodriguez, W., Kim, H., Brandt, C. et al. FECAL ADENOVIRUSES (FAd) FROM A LONGITUDINAL STUDY OF FAMILIES IN METROPOLITAN WASHINGTON DC: LABORATORY, CLINICAL & EPIDEMIOLOGICALOBSERVATIONS. Pediatr Res 18 (Suppl 4), 284 (1984). https://doi.org/10.1203/00006450-198404001-01149
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DOI: https://doi.org/10.1203/00006450-198404001-01149