Abstract
Serum IgE levels were measured in 394 twins and their parents. There were 116 monzygotic (MZ) twin pairs and 81 dizygotic (DZ) twin pairs. 85 twin pairs were younger than 15 years of age and 112 pairs were older. Mean IgE for MZ twins was 171.7 u/ml with a skewness of 7.7 and a kurtosis of 81.0 DZ twins had a mean of 159.7 u/ml. The sample curve was normalized by conversion to Log10 IgE. Correlation coefficients for Log10 are as follows:
These results suggest a very strong genetic and maternal influence on serum IgE levels. The r value for twins < 15 y/o was 0.2563,P=0.0179 while for older twins it was 0.4771,P=0.0001 suggesting that environmental factors are more important early in life and genetic factors predominate adulthood.
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Rodriguez, G. EVALUATION OF SERUM IGE LEVELS IN TWINS AND THEIR PARENTS. Pediatr Res 18 (Suppl 4), 263 (1984). https://doi.org/10.1203/00006450-198404001-01023
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DOI: https://doi.org/10.1203/00006450-198404001-01023