Abstract
Summary: The ability of standard phototherapy illumination to produce damage in intracellular DNA is well established. In this study, the addition of a dilute solution (1:6400) of a clinically-used multivitamin concentrate to human KB cells was found to enhance the generation of single-strand DNA breaks produced by broad-spectrum fluorescent light. The effect of the exogenous photosensitizing agent (multivitamins) was blocked by the enzyme catalase; thus, the photoproduct responsible for the DNA modification was hydrogen peroxide, an extremely reactive molecule capable of damaging a variety of biologic macromolecules.
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Ennever, J., Carr, H. & Speck, W. Potential for Genetic Damage from Multivitamin Solutions Exposed to Phototherapy Illumination. Pediatr Res 17, 192–194 (1983). https://doi.org/10.1203/00006450-198303000-00004
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DOI: https://doi.org/10.1203/00006450-198303000-00004