Abstract
Summary: Sucrase-isomaltase (SI) was isolated by immunoprecipitation from the intestines of human fetuses of 16–20 wk of gestational age as one large polypeptide (pro-SI) with a molecular weight of 260,000. Treatment with elastase converted the pro-SI into two polypeptides of apparent molecular weights as sucrase and isomaltase from normal adult intestine (Mr 140,000 and 150,000, respectively). The pro-SI had full enzymatic activity.
Speculation: The results indicate that human sucrase-isomaltase is synthesized as a single chain and that the pancreatic proteases play a significant role in the final processing of the molecule. The pro-SI is proposed to be present also in patients suffering from pancreatic insufficiency.
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Skovbjerg, H. High Molecular Weight Pro-Sucrase-Isomaltase in Human Fetal Intestine. Pediatr Res 16, 948–949 (1982). https://doi.org/10.1203/00006450-198211000-00009
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DOI: https://doi.org/10.1203/00006450-198211000-00009
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