Abstract
Summary: Several membrane properties of vitamin E-deficient and normal erythrocytes were studied after incubation of these cells with hydrogen peroxide. Measurements of mean corpuscular volume, cation permeability, membrane Na+, K+ ATPase activity, red cell filterability through 5 μ millipore filters, and membrane protein pattern on sodium dodecyle sulfate-gel electrophoresis revealed marked alterations before lysis. Vitamin E sufficient cells were unaffected by a similar incubation with hydrogen peroxide. We speculate that the changes in membrane function, which follow peroxidant injury, contribute to the shortened red cell survival in the vitamin E deficient state.
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Lubin, B., Chiu, D. Properties of Vitamin E-Deficient Erythrocytes following Peroxidant Injury. Pediatr Res 16, 928–932 (1982). https://doi.org/10.1203/00006450-198211000-00005
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DOI: https://doi.org/10.1203/00006450-198211000-00005
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