Abstract
Previous work has shown a decreased gastrin release in neonatal humans and swine in response to intragastric protein. To further study gastrin release in neonatal swine, serum gastrin determinations were made following intragastric instillation of protein and the amino acid cysteine, known to release antral gastrin in adult animals. Six animals, less than 48 hours of age, had catheters placed in the femoral and portal veins. In three animals, intragastric Sustagen (1.7 gm protein/kg) was followed by intragastric cysteine (100mM, pH 7.4 at 10 cc/kg), while three received cysteine. Simultaneous femoral and portal venous samples were analyzed for gastrin at 1, 5, 15, 30, 45 and 60 minutes. The simultaneous femoral and portal vein gastrins did not differ statistically at any time. Basal gastrin was elevated in all animals when compared to adult values (p<0.1). Following intragastric cysteine infusion, there was no significant elevation in gastrin in the portal (317 vs 264 pg/ml) or femoral (253 vs 254 pg/ml) veins. After protein challenge with Sustagen, there was a delayed, but significant, elevation in gastrin in portal and femoral samples at 30, 45 and 60 minutes (386 vs 573 pg/ml P.V. and 411 vs 569 pg/ml F.V.) (p<0.5). The results of these studies indicate a significant alteration in the release of gastrin in response to intragastric amino acids in the neonatal swine when compared to adult animals.
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Rodgers, B., Blake, K. & Moazam, P. 624 SERUM GASTRIN RESPONSE TO INTRAGASTRIC PROTEIN AND CYSTEINB IN NEONATAL SWINE. Pediatr Res 15 (Suppl 4), 544 (1981). https://doi.org/10.1203/00006450-198104001-00637
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DOI: https://doi.org/10.1203/00006450-198104001-00637