Abstract
Although many aspects of the biological activities of SRIF or somatostatin had been studied previously, its effects on body growth in relation to various blood hormones related to growth during pubertal development has not been clarified. In the current study SRIF (protamin-Zn) was administered S.C.(1mg/kg b.w.) to male Wistar rats daily over a period of 20-90 days of life, and body growth together with serum concentrations of GH,insulin,LH,FHS,T,DHA,SM(porc.cart.) and sugar were examined longitudinally. In parallel experiments effects of withdrawal of SRIF at various phases of development were also studied. Somatostatin inhibited secretion GH,insulin,and SM and had severe adverse effects on body growth and its velocity. Withdrawal of SRIF at various stages of life led to catch-up growth and normalization of GH and insulin levels. SM,however, remained low and DHA peaked in all animals. These multiple effects of SRIF leads to conclude that this hormone permanently blocks SM; and catch-up growth is perhaps SMindependent but GH and insulin dependent. Further, adrenarche is also present in the rat.
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Ranke, M., Hildebrand, P., Rudolph, C. et al. A longitudinal study of the effects of SRIF on growth and peripheral hormones in the male rat during pubertal developmant. Pediatr Res 15, 81 (1981). https://doi.org/10.1203/00006450-198101000-00058
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DOI: https://doi.org/10.1203/00006450-198101000-00058