Abstract
In a naturally occurring model of congestive cardiomyopathy (CCM) of turkeys, alterations of Ca++ transport in isolated cardiac sarcoplasmic reticulum (SR) were documented in the young CCM turkey at 1, 10, and 28 days of age; prior to the development of cardiac dilatation. Ca++ binding in CCM birds was reduced to 55-75% of values measured in age-matched commercial control turkeys (p<0.05 to <0.01)and Ca++ uptake was reduced to 52-87% of control values (p<0.05 to <0.01). Ca++ stimulated ATPase values at 1, 10, and 28 days of age were similar in CCM and control turkeys. However, at 56 days of age when all CCM birds showed marked to moderate left ventricular dilatation, Ca++ stimulated ATPase was reduced to 75% of control values (p<0.05). Cyclophosphamide immunosuppression of newly hatched CCM turkeys significantly elevated Ca++ binding and Ca++ uptake in isolated cardiac SR from 10-day-old birds by 73% and 58% respectively (p<0.05 and <0.01) over values measured in untreated CCM birds. These results were not significantly different from values obtained in 10-day-old control turkeys. In summary this unique depression of SR Ca++ uptake and Ca++ binding, prior to the onset of cardiac dilatation, and which is reversed by immunosuppression, provides an experimental link between this animal model and a proposed mechanism for the pathogenesis of congestive cardiomyopathy in man.
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Staley, N., Noren, G. & Einzig, S. 201 ALTERATIONS IN CARDIAC SARCOPLASMIC RETICULUM FUNCTION IN A CONGESTIVE CARDIOMYOPATHY MODEL. Pediatr Res 15 (Suppl 4), 473 (1981). https://doi.org/10.1203/00006450-198104001-00210
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DOI: https://doi.org/10.1203/00006450-198104001-00210