Abstract
Clinical SIADH and DI are seen with changes of ICP in acute encephalopathies. Changes in serum ADH {RIS} were correlated with direct measurements of ICP with a Richmond screw transducer, in 9 patients with Reye's syndrome. Serum ADH measured by method of Skowsky, with bentonite extraction to remove vasopressin from specimen. Extracts were resuspended in phosphate buffer & measured by RIA, utilizing 125I-AVP {2500 PM}, 100 ul. {Normal ADH x̄ ± 2 SD = -.1 to 3.54 uIU/ml}. All patients were in stage III or IV & had clinical & laboratory ADH alterations. ICP changes corresponded with serum ADH changes. Patients in stage I & II showed no clinical or laboratory ADH changes. SIADH is seen initially with serum ADH & ICP measurement rising together. Sustained increased ICP leads to DI, decreased serum ADH & a poor prognosis. Increased ICP may be associated with direct hypothalamic effects producing changes in ADH & appropriate correlated clinical syndrome.
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Brown, D., MacDonald, J. Antidiuretic Hormone Changes with Acute Increased Intracranial pressure {ICP}. Pediatr Res 15, 1569 (1981). https://doi.org/10.1203/00006450-198112000-00202
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DOI: https://doi.org/10.1203/00006450-198112000-00202