Abstract
In order to evaluate the regulating mechanism of the secretion of DHA, its response to ACTH (Synacten 0,15 mg/ m2 i.v.) was measured in 79 children: 34 with normvariant growth serving as controls (A), 27 with idiopathic hypotituitarism (B), 11 with Turner's Syndrome (C), 7 hypergonadotrophic hypogonad males (D). The children were divided into 3 groups: I.preadrenarche (B.A., 7.5 yrs), II. adrenarche (B.A. 7.5 yrs + no gonadarche), III. gonadarche. The facilatory effects on DHA in terms of peak/basal concentration ratio in the control groups showed that the responsiveness was highest in group All (N=16,B.A.=10.8) being 2.58 while in groups AI(N=5;B.A. 6.5) and AIII(N=13;B.A.=14.2) ratios were 1.58 and 1.31. The ratios in the groups with hypopituitarism paralleled the normal groups in relation to B.A.:BI(N=5;B.A.=6.6) ratio 1.66;BII(N=9;B.A.=10) ratio 2.26;BIII(N=6;B.A.=12.3) ratio 1.78. In 7 subjects of this group no response was seen. The ratio was 2.09 in group CII(N=11;B. A.=11.2) and 1.41 in group DNN(N=7;B.A.13.1). The present data - although limited - pose two questions: Does the DHA responsiveness to ACTH peak during the onset of adrenarche? Is this responsiveness more closely associated with bone age(B.A.) than with pubertal development?
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Ranke, M., Rosendahl, W., Bierich, J. et al. CHANGING RESPONSIVENESS OF DHA TO ACTH. Pediatr Res 15, 1559 (1981). https://doi.org/10.1203/00006450-198112000-00144
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DOI: https://doi.org/10.1203/00006450-198112000-00144