Abstract
How much will a child have grown this day twelvemonth, and when growth ceases? Longitudinal height and RUS BA data were used to calculate NYG and AFG for 49 HGH-treated hypopituitary children and 47 tall girls with or without oestrogen treatment. Centile standards for height velocity against RUS BA were derived from van Venrooij-IJsselmuiden (1978). As in normal children the highest NYG occurred during year following BA 11.0-11.9 in all groups of female patients and after BA 12.0-12.9 in males. In HGH-girls NYG varied from P50 to P10 at different BA's when puberty was spontaneous, and was below P10 in girls with gonadotrophin deficiency. In both types of HGH-boys NYG fluctuated around P50. In tall girls oestrogen treatment reduced NYG from P50-values to values at or below P10. AFG was calculated for 10 female and 10 male HGH-patients, and for 14 oestrogen-treated and 4 untreated tall girls. In HGH-girls with spontaneous puberty and in untreated tall girls average AFG values dropped sharply in one BA year from over 9 cm at BA 13.0-13.9 to less than 4 cm. In HGH-boys a comparable fall in AFG occurred following BA 14.0-14.9. Gonadotrophin deficient HGH-girls had very low AFG values, 5 cm at BA 12.0-12.9, 2 cm one BA year later. In tall girls high dose oestrogen treatment reduced AFG to 5 cm at BA 13.0-13.9. Results indicate growth potentials, relative to RUS BA at pubertal ages.
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Ten Bosch, J., Bot, A. Next year's growth (NYG) and all further growth (AFG) of short and tall children with RUS bone ages of 12 years and over. Pediatr Res 15, 1551 (1981). https://doi.org/10.1203/00006450-198112000-00099
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DOI: https://doi.org/10.1203/00006450-198112000-00099