Abstract
Present evidence indicates that phosphatidylglycerol (PG), phosphatidylinositol (PI), and phosphatidylserine (PS), in decreasing order, activate surfactant lecithin synthesis and maintain surface activity. Animal studies indicate that INO suppresses surfactant PG synthesis. We have studied serum INO levels in newborns with RDS and in adults with ARDS. The INO levels have been correlated with phospholipid (PL) levels from tracheal aspirates (newborns) or alveolar lavage (adults). During 1st neonatal day INO levels were significantly higher in RDS (n=7) than in no RDS (n=12) [mean 1004 (530-2830), vs 179(58-345)μM, p<0.005]. As studied in 4 cases, INO decreased before PG appeared [1st day: 1738 (530-2830), vs 3rd day:510(280-1380) μM, p<0.05]. In 6 ARDS cases PL's were different from 11 cases without ARDS:
The two ARDS cases with highest INO (395 and 470 μM) had renal failure. Absence of PG in RDS may be mainly due to high INO and in ARDS mainly to deficient PG+PI synthesis. We propose that INO is synthesized at the expense of surfactant PL. Thus serum INO may be helpful in monitoring the course of RDS.
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Hallman, M., Saugstad, O., Epstein, B. et al. 1661 ACIDIC SURFACTANT PHOSPHOLIPIDS IN RDS AND IN ADULT RDS (ARDS): ROLE OF MYOINOSITOL (INO) IN REGULATION. Pediatr Res 15 (Suppl 4), 720 (1981). https://doi.org/10.1203/00006450-198104001-01679
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DOI: https://doi.org/10.1203/00006450-198104001-01679
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