Abstract
In 10 normal infants and 14 BA infants ICP changes were studied by a noninvasive technique (Iadd Monitor). Systemic BP,mean ICP and CPP(Mean BP-ICP) were calculated during acute phase(3 days) and recovery (6 days) in BA infants. 4 infants died and had evidence of brain damage and 2 of the 10 survivors had cerebral palsy (CP) at 3 years. 8 remaining survivors were normal(26-46 mos)Clinical, ICP and CPP values from normals. (Gr.I) BA with normal long term outcome(Gr.II), BA with brain damage (Gr.III) are shown below:(values mean + SE) *p<0.05 **p<0.025 + p<0.001. CPP during acute phase was low in Gr.II and improved during recovery. In Gr.III profound falls of CPP were due to elevation of ICP (cerebral edema) and fall of BP. In 12 infants who had accurate CPP measurements, 6 had CPP <30 Torr (mean-3 SD). 5 of these had brain damage and the other has amblyopia. None of 6 with >30 Torr CPP had brain damage. We conclude: A)Very low CPP in BA infants is associated with brain damage. (p=0.015, Fishers Ex.Test), B) CPP should beutilized in the management and to prognosticate the outcome.
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Raju, T., Vidyasagar, D. & Doshi, U. 1603 CEREBRAL PERFUSION PRESSURE(CPP) IN BIRTH ASPHYXIA(BA) AND ITS RELATION TO THE QUALITY OF OUTCOME. Pediatr Res 15 (Suppl 4), 710 (1981). https://doi.org/10.1203/00006450-198104001-01620
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DOI: https://doi.org/10.1203/00006450-198104001-01620