Abstract
Fluid overload in VLBW infants and induced hypertension in animals have been implicated in the etiology of ICH. We compared 51 clinical and biochemical variables from 34 VLBW infants with autopsy proved severe ICH, and 38 randomly selected control infants (C). No differences were found between the groups in:4 prenatal stress factors,mode of presentation and delivery, admissionblood gases and diagnosis. ICH group had 2/3 symptoms of severe ICH by 29.8±20 (SD)hours. C infants had no symptoms, normal CSF and are developing normally. B.Wt and G.A. were,ICH:0.93kg and 28Wks: C group 1.2kg and 30 Wks (p<0.05).Other results, (x± SE values)are in the Table. ICH infants were smaller, 1.5 Wks less mature, more asphyxiated and colder on admission.(*p<.05)They received slightly more fluid (N.S) on day 1. On day 2 however, they became more symptomatic, had elevated mean BP, and had received about 30ml/Kg. more fluids(*p<.05). We feel that in VLBW infants, asphyxia sets up a stage for ICH.Vigorous resucitation, and rapid volume expansion trigger a hypertensive response precipitating the final episode of massive ICH.
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Raju, T., Cybulski, G., Ramlrez-Lavin, G. et al. 1602 ASSOCIATION OF HYPERTENSION AND FLUIDS WITH CLINICAL MANIFESTATION OF SEVERE INTRACRANIAL HEMORRHAGE(ICH) IN VERY LOW BIRTH WEIGHT INFANTS. Pediatr Res 15 (Suppl 4), 710 (1981). https://doi.org/10.1203/00006450-198104001-01619
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DOI: https://doi.org/10.1203/00006450-198104001-01619