Abstract
Intraventricular hemorrhage (IVH) has been found to occur in as many as 50% of premature infants, but its presence does not correlate well with symptoms or with cerebrospinal fluid values. CSF lactate dehydrogenase (LDH) is elevated in adults with intracranial hemorrhage (Henry, 1979). The usefulness of CSF LDH as a possible indicator of the presence and severity of IVH was evaluated in 22 premature neonates, 10 of whom had IVH by computerized tomography (CT) scan. (3 Gr.I, 3 Gr.II, 1 Gr.III, 3 Gr.IV)
Spinal fluid LDH was significantly greater in the group with IVH, p<0.001 by the Mann-Whitney rank test. There was no overlap in the LDH values between the IVH and no IVH groups.
In addition, the LDH values correlated well with the grade of IVH on CT scan. Other CSF and clinical parameters were analyzed and will be discussed. It is suggested that spinal fluid LDH may provide an index of the presence and severity of IVH in the newborn.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Engelke, S., Saldanha, R., Kopelman, A. et al. 1574 CEREBROSPINAL FLUID LACTATE DEHYDROGENASE IN INTRA-VENTRICULAR HEMORRHAGE OF THE PREMATURE. Pediatr Res 15 (Suppl 4), 705 (1981). https://doi.org/10.1203/00006450-198104001-01591
Issue Date:
DOI: https://doi.org/10.1203/00006450-198104001-01591