Abstract
We tested the hypothesis that elevation of intracranial pressure (ICP) produces redistribution of cardiac output. Nine lambs (3 months old) were anesthetized with pentobarbital and pancuronium, and ventilated. ICP was increased by infusing mock CSF into the right lateral ventricle. Regional blood flow was measured with the radiolabelled microsphere technique at two control levels separated by 1.5 hr, and at two different elevations of ICP, each maintained for 10 minutes. Elevation of ICP to 53±5 (SE) mmHg at a mean arterial pressure (MABP) of 102±6 mmHg (cerebral perfusion pressure (CPP)=50±3) resulted in a 7±3% decline of cerebral blood flow (CBF). At this level of ICP, there was no reproducible pattern of change in regional blood flow to intestines, kidney, spleen, liver, pancreas, adrenals, skin or skeletal muscle. Severe elevation of ICP to 93±4 mmHg, produced an increase in MABP from 108±6 to 118±7 mmHg, and a 30±6% fall in CBF (CPP = 24±5). Hepatic arterial flow decreased by 35±14%. Skeletal muscle flow increased by 85±34%. There was no consistent blood flow change in other organs studied. However, in lambs in which cerebral O2 consumption fell by more than 10% (n=4), renal and skin flow decreased by 14 ±4% and 16±1%, respectively. These data indicate that severe elevations of ICP sufficient to cause cerebral ischemia result in differential distribution of cardiac output.
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Baekofen, J., Koehler, R., Jones, M. et al. 1558 EFFECT OF ELEVATED INTRACRANIAL PRESSURE OH DISTRIBUTION OF CARDIAC OUTPUT IN YOUNG LAMBS. Pediatr Res 15 (Suppl 4), 703 (1981). https://doi.org/10.1203/00006450-198104001-01575
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DOI: https://doi.org/10.1203/00006450-198104001-01575