Abstract
Renal functions, cardiac output(CO) and colloid oncotic pressure (COP)were measured during control (C) hypovolemic shock (HS) and recovery (R) in baboons (2-8 weeks). Heart rate, mean blood pressure (MBP) and tissue pH (tpH) were monitored continuously. Shock was induced by bleeding till the MBP dropped from 81 to 41 mmHg. CO, blood gases (ABG), COP, Hct were measured every 15′. GFR, PAH and osmolar clearance, FEna were measured during C, HS, R. GFR, CPAH and COSM decreased significantly during HS (p<0.5) but recovered to baseline following reinfusion. In newborns both Fena and Uv decreased by 85%. Whereas in the older baboons the decrease was 52 and 85% respectively. CO and MBP decreased by 50%, but recovered following reinfusion. These findings suggest that: 1) The decrease in GFR and Uv is due to decrease in CO and MBP; 2) The decrease in FEna in the presence of decreased GFR, PAH, COSM suggests an intact tubular function; 3) All the parameters recovered following infusion. In conclusion, the changes in renal function in early HS (45′) are transient and reversible following reinfusion. *(p<.05)
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Bhat, R., John, E., Braverman, B. et al. 1484 RENAL FUNCTIONS FOLLOWING ACUTE HYPOVOLEMIC SHOCK IN DEVELOPING BABOONS. Pediatr Res 15 (Suppl 4), 690 (1981). https://doi.org/10.1203/00006450-198104001-01513
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DOI: https://doi.org/10.1203/00006450-198104001-01513