Abstract
To evaluate the effects of inspiratory flow resistance (RI) on ventilatory response, 7 infants recovering from RDS were studied: Mean wt. 1.6 kg, age 21 days, gest. age 32 wks. Control tidal vol. (TV), min. vent. (MV), peak insp. flow (VI), insp. time/tot. resp. time (TI/TTot), resp. freq. (f), dynamic compliance (CL) and PACO2 were obtained before applying a 250 or 450 cm H20/L/sec. RI. Studies were repeated immediately, 5 and 10 minutes following application of RI. Infants were breathing room air throughout the study. Mean ± SEM control values were: TV=14.4±6.5 ml, MV=804.8±313.8 ml/min, VI=2.13±1.08 L/min, TI/TTot=.44±.03, f=53.66±10.91, CL=3.46±1.48 (n=5), PACO2=41.1±4.5 mmHg. Following application of a RI of 450 cm H2O/L/sec there was a decrease immediately and at 5 and 10 minutes for: TV(ml)=7.0±3.8 (p<.002), 7.5±4.9 (p<.0001), 8.0±5.4 (p<.001). MV(ml/min)=329.6±145.3 (p<.001), 385.2±227.2 (p<.0001), 377.9±254.4 (p<.0001). VI(L/min)=.50±.34 (p<.002), .53±.34 (p<.002), .58±.45 (p<.002) respectively. There were no sig. changes in f, TI/TTot, PACO2 after loading, nor sig. diff. between the 250 and 450 insp. loads These demonstrate a progressive decrease in resp. response in infants recovering from RDS after insp. loading of 250 and 450 cm H2O/L/sec. It appears that infants recovering from RDS do not compensate for insp. loading and this lack of compensation may be responsible for some forms of neonatal obstructive apnea.
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Abbasi, S., Duara, S., Shaffer, T. et al. 1228 EFFECTS OF INSPIRATORY LOADING ON VENTILATION IN INFANTS RECOVERING FROM RESPIRATORY DISTRESS SYNDROME (RDS). Pediatr Res 15 (Suppl 4), 647 (1981). https://doi.org/10.1203/00006450-198104001-01254
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DOI: https://doi.org/10.1203/00006450-198104001-01254