Abstract
Young mice treated with Toximul MP8, a polyoxyethylene ether based emulsifier, show an increased mortality when infected with encephalomyocarditis virus (EMC) than do control mice. Lymphocytes taken from these emulsifier treated mice respond poorly to interferon induction, as compared to controls. Interferon also protects control mice against EMC infection but such protection is reduced in emulsifier-treated mice. This enhanced lethality to EMC in emulsifier-treated mice may be due to compromised interferon response in these animals.
Blood samples were obtained from a group of Reye's patients in the acute and convalescent phase of their disease. Lymphocytes were induced to synthesize interferon by Newcastle Disease Virus. Peripheral blood lymphocytes from convalescent patients and controls responded well to interferon induction. Lymphocytes taken in the acute phase of children with Reye's syndrome produced significantly less interferon than those from recovering patients or controls. Since Reye's syndrome is an unusual response on the part of the host following a virus infection our data would appear to implicate interferon as part of this altered response.
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Rozee, K., Lee, S., Arcinue, E. et al. 997A A COMPROMISED INTERFERON RESPONSE: AN ETIOLOGIC FACTOR IN REYE'S SYNDROME. Pediatr Res 15 (Suppl 4), 609 (1981). https://doi.org/10.1203/00006450-198104001-01023
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DOI: https://doi.org/10.1203/00006450-198104001-01023