Abstract
Trisomy 13 occurs with an incidence of 1/8000 live births. Thirty-one patients with Trisomy 13 diagnosed over the past 19 years at our institutions were reviewed. Parameters evaluated were age of parents, sex, occupation, prenatal history, parity, family history, geographic area, clinical features, and birth month. 23/31 (74%) were male; three periods of the year with higher incidence (28/31) were found (March-April, July-August, and November-December); mean age of mother was 29.6 years (median 28 years). Trisomy 13 in our patients was associated with increased parity. Family history revealed 2 patients who had relatives with Trisomy 21; 2 patients had relatives with polydactyly; 2 patients had relatives with cleft lip/palate. These data refute previous data which indicate a sex ratio in Trisomy 13 of 1:1 and 2 maternal age peaks. In addition, the data support a higher incidence in males, 3 peak months of occurrence, an increased risk with increased parity. The occurrence in the family of cleft lip/palate and polydactyly, which are characteristic features of Trisomy 13 syndrome, as well as other trisomies suggests that there may be other genetic influences affecting non-disjunction in families.
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Moteleone, P., Anderson, R., Chen, SC. et al. 741 A DEMORAPHIC STUDY OF TRISOMY 13. Pediatr Res 15 (Suppl 4), 565 (1981). https://doi.org/10.1203/00006450-198104001-00764
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DOI: https://doi.org/10.1203/00006450-198104001-00764