Abstract
The remission in type I D.M. is characterized by a low insulin requirement, no glucose excretion and detectable serum C-peptide. The initial hemoglobin Alc. (HbAlc) concentration determines the duration of the remission: a high HbAlc is followed by a short and a low HbAlc -concentration by a long remission phase (Vetter et al., Ped.Res. 13, 1190 (1979)). In the present study of 21 newly diagnosed children with type I D.M. the following parameters were determined: initial HbAlc -concentration, the time (days of glycosuria), the mean insulin dosage (U/kg/day) to recompensate the carbohydrate metabolism, and the duration of the remission.
Results: the regression analysis revealed: HbAlc vs. mean insulin dosage r=0.92; p<0.001; HbAlc vs. duration of glycosuria r=0.63; p<0.01 and HbAlc vs. duration of remission r= -0.84; p<0.001; mean insulin dosage vs. duration of remission r= -0.76; p<0.001.
Conclusion: the initial metabolic derangement of type I D.M. seems to determine the duration of the remission. Early diagnosis and strict treatment may prolong the duration of the remission phase.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vetter, U., Heinze, E., Kohne, E. et al. METABOLIC DECOMPENSATION AND DURATION OF REMISSION PHASE IN TYPE I DIABETES MELLITUS (D.M.). Pediatr Res 15, 88 (1981). https://doi.org/10.1203/00006450-198101000-00103
Issue Date:
DOI: https://doi.org/10.1203/00006450-198101000-00103