Abstract
The nephrotoxicity of G has been related to its binding to renal tissue which accounts for a prolonged elimination phase. The bi-exponential profile during washout analyzed according to a two compartment model can provide predictive data on the accumulation of G in blood and tissues. The ratio of tissue to total body amount of G at steady state can be estimated to be about .8 in the adult.
By the same analysis we have calculated the terminal elimination half life(T1/2), the volume of the central compartment,including blood(Vc), the steady state volume of distribution(Vdss), the body clearance(Clb) and the predicted amounts of G at steady state in the body(Xb) and tissues(Xt) of 18 premature neonates (27-38 wks g.a. and 8-14 days p.n.age), 4 infants (2-5 mo) and 3 children (5-9 yrs). Mean data and ranges were the following :
The data show that changes in G kinetics occur with age and predict a lower accumulation in the tissue compartment of our patients than expected from adult data.This could account for a lower nephro toxicity of G in early development.
Supp. by CNR grant, Rome,Italy, Programme of Preventive Medicine n° 78.00635.83115.4019.
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Assael, B., Cavanna, G., Jusko, W. et al. MULTIEXPONENTIAL ELIMINATION OF GENTAMICIN(G). A KINETIC STUDY DURING DEVELOPMENT: 23. Pediatr Res 14, 170 (1980). https://doi.org/10.1203/00006450-198002000-00050
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DOI: https://doi.org/10.1203/00006450-198002000-00050