Abstract
The effect of transplacental antibody on the immunresponse to Bovine Serum Albumin (BSA) normally present in infant formulas was assessed in 15 healthy neonates. Anti-BSA, determined by the Farr-assay using Ing +I-BSA-N/ml, was considered present if sera bound > 10% of +I-BSA. If >25% of +I-BSA was bound, an antigen-binding-capacity (ABC) was calculated and expressed as ng BSA-N bound by 1 ml of serum. 7 infants (group I) with anti-BSA in their cordblood were compared to 8 infants without passive anti-BSA (gr. II). The development of anti-BSA (ABC) and IgG (mg/ml, gr. I and II combined) are shown in the table.
The finding of a significantly higher ABC in gr. II (at 8 weeks p=0.05) suggests that passive antibody may modify the response to oral antigens although it does not prevent active antibody formation in early life. Supported by DFG-Grant Ri 345/1.
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Müller, W., Rieger, C. & Brodehl, J. Kinderklinik der Medizinischen Hoohschule Hannover, 3 Hannover 61, W.-Germany. Pediatr Res 14, 1427 (1980). https://doi.org/10.1203/00006450-198012000-00115
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DOI: https://doi.org/10.1203/00006450-198012000-00115