Abstract
In the decade 1970-79, NEC was observed only in the period '76-'79, and only in infants weighing ≤ 1250 g, with sepsis and surviving at least 48 hours. In 1978 a trial of PMNs transf. to septic infants was started. In septic infants with the above characteristics admitted in '76-'79, we considered the following items: sex, weight, GA, SBP, a-b status, temp. on adm., umb. vessels catheterization, feeding schedules, blood culture, clinical signs, antibiotic and PMNs transf. therapy, and occurrence of NEC. The 10 patients with and the 28 pts. without PMNs were similar for the above items, except that NEC occurred in 10/28 pts. without PMNs transf., and never in the 10 transfused pts. (p = 0.03). The 10 pts. with NEC and the 28 pts. without NEC were similar for the above items, except that PMN transf. had been given to 10/28 of the non-NEC pts., and never to the NEC pts. (p = 0.03). It is suggested that PMNs transfusion prevents the occurrence of NEC in septic very low birthweight infants.
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Panero, A., Marzetti, G., Laurenti, F. et al. ABSENCE OF NECROTIZING ENTEROCOLYTIS (NEC) IN SEPTIC LOW BIRTHWEIGHT INFANTS TREATED BY POLYMORPHONUCLEAR LEUKOCYTES (PMNs) TRANSFUSIONS. Pediatr Res 14, 1424 (1980). https://doi.org/10.1203/00006450-198012000-00093
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DOI: https://doi.org/10.1203/00006450-198012000-00093