Abstract
RESPONSE OF BONE AND KIDNEY TO PARATHYROIDEA EXTRACT(PTE) IN CHILDREN RECEIVING ANTICONVULSANT DRUGS Antiepileptic drugs (a.d.) may interfere with the action of PTH on bone in vitro. The aim of the present study was to investigate the in vivo response of bone and kidney to PTE in epileptic children on long-term treatment with a.d. In six epileptic patients (P) with normal serum iPTH levels and two boys with untreated idiopathic hypoparathyroidism (H) a)urinary total hydroxyproline (OH-P) and serum calcium (Sca)before and during prolonged PTE administration and b) urinary (UcAMP) and plasma cyclic AMP (PcAMP) and the percent tubular reabsorption of phosphate (TRP) before and after PTE infusion over 15 min. were measured. a) Maximal Sca increase was 2.3-6.4 mg/dl in P and 4.9-6.1 mg/dl in H. The percental rise of OH-P was 105-229 in P and 100-121 in H. b) UcAMP increased 17-89 fold in P and 92-169 fold in H, PcAMP increased 13-28 fold in P and 15-23 fold in H. TRP fell 3.5-8.1 % in P and 24-34% in H (normal: 10-30 %) after PTE infusion.
Conclusion: a) The normal increase of Sca and OH-P indicates that inhibition of PTH-mediated resorption of ca from bone is not a significant factor in anticonvulsant related disturbance of ca metabolism. b) The dissociation between cAMP excretion (normal) and phosphate (decreased) resembles type II pseudohypoparathyroidism.
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Kruse, K., Bartels, H. RESPONSE OF BONE AND KIDNEY TO PARATHYROIDEA EXTRACT(PTE)IN CHILDREN RECEIVING ANTICONVULSANT DRUGS. Pediatr Res 14, 1419 (1980). https://doi.org/10.1203/00006450-198012000-00063
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DOI: https://doi.org/10.1203/00006450-198012000-00063