Abstract
Summary: A solid-phase radioimmunuassay has been developed for the titration of TbIgG (trypsin binding IgG) in sera of CF parients. Using this assay system it has been found that TbIgG are primarily directed against porcine trysin and cross-react with human trypsin. A specific subpopulation of anti-human trypsin antibodies has not been found, making unlikely the occurrence of an autoimmune process in GF, at least against human panereatic enzymes.
Speculation: It is known that anti-proteins antibodies modify the turnover in the circulation of free portliness, which are usually bound and rapidly sequestered by globulin. Oblige might create the conditions by which part time try sin, and possibly human activated trypsinogen, could be present in the circulation in the form of immune complexes.
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Denaro, M., Romeo, G. Antibodies Cross-Reacting with Porcing and Human Trypsin in Cystic Firosis. Pediatr Res 14, 1086–1087 (1980). https://doi.org/10.1203/00006450-198009000-00014
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DOI: https://doi.org/10.1203/00006450-198009000-00014