Abstract
Endogenous renal transport of free amino acids was determined in 28 patients with INS aged 3-17 years. GFR measured concomittantly by inulin was 117.3 ml/min/1.73 m2. Values of the serum concentrations, urinary excretion, renal clearance rates, net tubular reabsorption and percentage tubular reabsorption of 19 amino acids were determined by ion exchange chromatography. The results were compared with values of 12 healthy children without renal disease between the age of 2-13 years (Brodehl,J.,K.Gellissen,Pediatrics 42:395,1968). The serum values of aspartic acid, serine, cystine, tyrosine, ornithine and lysine were significantly higher and the values of phenylalanine and histidine lower in INS as compared to healthy children. The urinary excretion of isoleucine was higher, the excretion of methionine and histidine and the clearance rates of histidine and cystine were lower in INS. The net tubular reabsorption of proline, phenylalanine and histidine were significantly lower in INS. But the percentage tubular reabsorption of all amino acids did not differ significantly. During relapse and under the influence of corticosteroids percentage tubular reabsorption was lower.
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Weber, HP., Hildenbrand, G. & Liappis, N. ENDOGENOUS RENAL TRANSPORT OF FREE AMINO ACIDS IN CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME (INS). Pediatr Res 14, 1005 (1980). https://doi.org/10.1203/00006450-198008000-00193
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DOI: https://doi.org/10.1203/00006450-198008000-00193