Abstract
Patients with INC had immunologic studies in 3 stages of their illness: I-heavy proteinuria pre-treatment or within 2 weeks of adrenal corticoids or cyclophosphamide; II-after 2 weeks of therapy with continued proteinuria; III-in remission off therapy. Measurements included: serum CH50 and immunoglobulins; lymphocyte transformation (LT) and E rosettes and leukocyte migration inhibition (MIT) using fetal kidney cortex as antigen (normal: 0.9 + 0.14).
Three of 12 INC patients had low CH50 in I; serum IgG and IgA were low in I, returning to normal by III, but IgM was elevated in all three stages. LT and E rosettes were normal in 80% (all stages). Conclusions: (1) cell mediated immunity (CMI) to renal antigens was evident in INC and subsided with disease activity; (2) low IgG and IgA in I may reflect urinary loss or a defect in T lymphocytes leading to predominant IgM synthesis in response to antigen challenge; (3) whether or not INC is due to CMI or immune deficiency awaits further study.
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Wang, B., Wang, P. & Chang, W. PRELIMINARY OBSERVATIONS ON IMMUNOLOGIC CHANGES IN IDIOPATHIC NEPHROSIS OF CHILDHOOD (INC). Pediatr Res 14, 1001 (1980). https://doi.org/10.1203/00006450-198008000-00170
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DOI: https://doi.org/10.1203/00006450-198008000-00170