Abstract
To know the role of HBs antigenemia in renal diseases in children,the incidences of positive HBs antigenemia by histology were compared,and clinico-immuno-pathological study was performed in 9 cases of positive antigenemia with nephrotic s.or abnormal urine.
HBs antigenemia was highly positive in MPGN and/or MN groups, although no significant difference between 2 entities. A case with acute HB hepatitis c̄ hematuria with transient HBs for 6 ms after hepatitis and a case with nephrotic S. and elevated serum IgE with transient HBs for 1 month both showed MC,wheras the other 7 cases with persistent HBs antigenemia and high incidence of persistent e antigenemia(6/7) revealed marked renal pathology:MPGN(3 cases), MN(3 cases) and PGN(1 case). HBs antigen was positive by IF only in a case with acute hepatitis and negative in 2 cases examined. Immune complex was positive in 3 cases in 3 examined by Rajii cell method and Clq solid phase EIA.Low C3,4,C1q were confirmed in 7/9.
The data suggests pathognomonic role of HBs antigenemia in MPGN as well as MN in chidren.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamashita, F., Matsuo, H., Yoshimoto, M. et al. HBs ANTIGENEMIA ASSOCIATED NEPHROPATHY IN CHILDREN. Pediatr Res 14, 997 (1980). https://doi.org/10.1203/00006450-198008000-00145
Issue Date:
DOI: https://doi.org/10.1203/00006450-198008000-00145