Abstract
These studies were designed to determine whether the effect of CPUO on the renal tubule is dependent upon the pattern of transport prevailing at various stages of development. Guinea pigs (n=78) underwent CPUO at birth, 1,2,3 or 4 wks of life and were studied 4 wks later (E). Sham operated littermates served as controls (C). The degree of CPUO, measured by the resistance to a constant flow of fluid, was similar in all groups. TRP averaged 87% in C, was slightly lower in the contralateral kidney (CK) of E (82%) and did not vary with age, whereas it increased with age (p<.05) from 46.6±6.1 to 68.0±6.3% in the affected kidney (AK). FeNa in AK was 7.5±.5 when CPUO was produced at birth and 4.8±1.0 when surgery was done at 4 weeks (p<.05). In C and CK, FeNa was much lower than in AK (p<.001), similar to each other and also decreased with age. UkV (mEq/min/g KW) varied inversely with FeNa in AK. Umax/Posm of C and CK in E were similar (range 4.0-4.3), while the ratio was not different from 1.0 (p>0.9) in AK at all ages. UV (μl/min/100 ml GFR) of the AK was 22.4 ± 3.7 when surgery was performed at birth, 26.7 ± 4.0, when surgery was done at 1 wk, and then decreased rapidly to reach 5.8 ± 1.2 when CPUO was produced at 4 wks (p<.001); no significant differences in UV were observed between C and the CK of E at any age. The results demonstrate an inverse relationship between age at time of CPUO and severity of tubular damage, and suggest the possibility of a major role for the distal nephron in P transport during early life.
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Taki, M., Goldsmith, D. & Spitzer, A. THE EFFECT OF CHRONIC PARTIAL URETERAL OBSTRUCTION (CPUO) ON RENAL TUBULAR TRANSPORT DURING MATURATION. Pediatr Res 14, 986 (1980). https://doi.org/10.1203/00006450-198008000-00080
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DOI: https://doi.org/10.1203/00006450-198008000-00080