Abstract
A nasogastric load of 2,7 g/kg of lipids with 67 % of medium chain triglycerides and 30 % of grape seeds oil was given at the age of 48 hours to 20 preterm neonates (mean bw = 2164 g ; gest. age : 35 weeks). Its effect on the concentrations of plasma glucose free fatty acids (FFA), serum B-OH-butyrate (BOHB) and lactate was compared to their evolution in 11 control preterm infants (mean bw 2102 g ; gest. age : 35 weeks). The basal levels were similar in both groups. In the supplemented group, plasma glucose increased from (mean ± SD) 57 ± 7 to 74 ± 11 mg/dl at 30 min. (p < 0.001) and to 80 ± 11 mg/dl at 60 min. (p < 0.001) while no significant change was recorded in the control group. At 60 min., serum BOHB had increased in the supplemented group from 339 ± 165 to 631 ± 230 μmol/l (p < 0.01) and it was higher than in the control group : 439 ± 200 μmol/l (p < 0.05). Plasma FFA decreased from 303 ± 178 to 199 ± 90 μlEq/l (p < 0.05) in 60 min. in the control group while no significant change was observed in the supplemented group. Serum lactate decreasedin 30 min. from 1777 ± 809 to 1257 ± 375 μmol/l in the supplemented group (p < 0.05) while the change (from 1820 ± 600 to 1581 ± 438 μmol/1) was not significant in the control group. In 7 supplemented infants, there was no change of serum insulin or glucagon concentration and no change of serum glycerol levels in 6 other supplemented infants.
These data suggest that in preterm infants 1)this load of triglycerides can provide glucose and ketone bodies which could be available for the neonatal brain 2)this hyperglycemic effect independant of hormonal influence is probably achieved through gluconeogenesis.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sann, L., Mathieu, M., Lasne, Y. et al. Hyperglycemic effect of an oral load of triglycerides in preterm neonates: 59. Pediatr Res 14, 175 (1980). https://doi.org/10.1203/00006450-198002000-00086
Issue Date:
DOI: https://doi.org/10.1203/00006450-198002000-00086