Abstract
Fourteen cases of primary congenital hypothyroidism aged 1 month to 9 years 6 months were followed with regular determinations of serum thyroid hormones. During 2 to 6 years follow-up, mean dose of dessicated thyroid gland powder was 63 ± 25 mg/m2/day (mean ± S.D.). This dose corresponds to a mean serum thyroxine concentration of 82 ± 32 μg/1. With a dose of 88 mg/ m2/day (mean + 1 S.D.) all the thyroxine levels were above the lower limit of normals. With such a dose, a normal growth was assumed, as well as a catch-up growth in the patients who had a retarded growth. A good psychomotor development was observed in the early-treated patients. Serum 1-tri-iodo-thyronine levels were not useful because of the wide fluctuations observed. Serum TSH levels were all under the lower limit of the normals with a dose of 88 mg/m2/day. In conclusion, regular measurements of serum thyroxine during therapy seem to be an adequate parameter for determining the dose of thyroid gland extracts adequate for substitution.
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Sizonenko, P., Gretillat, A. & Paunier, L. Usefulness of serum thyroid hormones determinations for the follow-up of treated congenital hypothyroidism. Pediatr Res 13, 77 (1979). https://doi.org/10.1203/00006450-197901000-00048
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DOI: https://doi.org/10.1203/00006450-197901000-00048