Abstract
About 8000 receptors are present on human lymphocytes of healthy persons at a dexamethasone concentration of approximately 2×10−6 M.We studied the behaviour of the corticosteroid-receptors present on lymphocytes and on platelets in dependance on structure and concentration.It was found that the cortico-steroidreceptors present on platelets have a higher affinity than those on lymphocytes.This is documented by a higher reactivity and a lower saturation concentration.At 37° the saturation of the receptors occurs on platelets within 15 min. and on lymphocytes after 45 min. at a corticosteroidconoentration of about 2×10−6 M. The saturation concentration of dexamethasone for platelets is about 5×10−7 M,for lymphocytes approximately 2×10−6 M. The affinity of the receptors measured on behalf the saturation concentration depends on the structure of the corticosteroid investigated. We found that 6-α fluorination increases the affinity of a corticosteroid against lymphocyte receptors.The number of receptors however is independent from the corticosteroid used,but varies from person to person. For healthy persons we found about 25 receptors per platelet, and about 6000 to 8000 receptors per lymphocyte.At physiologic corticosteroidconcentrations 1 or 2 corticosteroid molecules are bound on 1 platelet and about 50 molecules can be measured on 1 lymphocyte.
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Gleispach, H., Schumik, D., Zollner, H. et al. Corticosteroidreoeptors on human lymphocytes and platelets. Pediatr Res 13, 1197 (1979). https://doi.org/10.1203/00006450-197910000-00102
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DOI: https://doi.org/10.1203/00006450-197910000-00102