Abstract
In prepubertal boys and girls, a sleep-related increase of FSH occurred, followed by a sleep-related increase of LH at puberty. These rhythms developed later in boys than in girls. Concomitantly to the occurrence of sleep-related gonadotropin rhythms, an increased PRL-release was always present in all children. The hormonal variations of 3 girls with premature thelarche are compared to those of normal developed children. All of them demonstrated advanced bone-age of more than 2 years. In comparison, increased basal FSH and normal basal LH levels were found together with a sleep-related increase of both hormones. After LRH a more pronounced response occurred. After a 4 month period receiving daily 150 mg/m2 body surface CA orally, LH was depressed without increasing levels at sleep, whereas FSH still increased during sleep. Basal PRL levels increased from 5-7ng/ ml to 20-25ng/ml. An interfering action of CA at hypothalamic and/or pituitary levels has to be discussed as well as the observations that high PRL levels demonstrate an antigonadotropic effect too.
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Beck, W. Diurnal variations of LH,FSH and PRL in normal children and in 3 girls with premature thelarche before and after cyproteroneacetatetherapy (CA). Pediatr Res 13, 1196 (1979). https://doi.org/10.1203/00006450-197910000-00097
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DOI: https://doi.org/10.1203/00006450-197910000-00097