Abstract
To clarify the influence of a glucose load (Gl) on the thermogenetic effective thyroid hormones T4 and T3 plasma levels of obese children were studied after oral and intravenous glucose load during the postprandial period. T4-values decreased by 31% in a group of 14 obese children (overweight 17-100%) 60 min. after oral G1. This change was associated with an increase of T3/T4-quotient to 50-60% 60 min. after i.v. G1 T4 -values also were reduced 15,5% in normal weight (5) and 14% in 40 obese children. After feeding a diet of 600-1000 Kcal/die (30% protein, 45% carbohydrate, 25% fat) for a period of 21 days in 14 obese children T3-values decreased after oral G1. T3/T4 quotient was diminished to 69,4% after 60 min. After a 5-7 days fasting period T4 increased significantly (p 0,001) in 15 obese children. In a group of patients with an overweight of 40-60% also a significant T4-increase was found after i.v. G1, but not in a group with an overweight of 21-40%. It is concluded that glucose stimulates and fasting and a hypocaloric diet reduce the peripheral T4/T3 conversion in obese children.
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Hesse, V., Spahn, U. & Plenert, W. Glucose induced changes of thyroxine (T4) and triiodothyronine (T3) plasma levels in obese children before and after hypocaforic diet and fasting. Pediatr Res 13, 1185 (1979). https://doi.org/10.1203/00006450-197910000-00030
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DOI: https://doi.org/10.1203/00006450-197910000-00030