Abstract
The efficacy of Viokase, Cotazym and Pancrease on fat and nitrogen absorptions were assessed in 12 cystic fibrosis patients, ages 8 to 14 years in a metabolic unit. Dietary intake was fixed for the entire study period for each patient. Mean intake of calories was 81 Kcal/Kg/d, fat 2.7 Gm/Kg/u and protein 3.0 Gm/Kg/d. 3 dosage levels of each preparation were used; Viokase 4,8 or 12 tablets, Cotazym 2,4 or 6 capsules and Pancrease 1,2 or 3 capsules per meal per metabolic period. Patients were randomly assigned to 1 of 2 study groups; Viokase or Cotazym verus Pancrease. Fat and nitrogen absorptions were significantly increased on each preparation over the placebo. But no significant difference in absorption was noted between the 3 preparations at each dosage level. The results of this study indicate that Pancrease, a pH sensitive enteric coated microspherules pancreatin preparation is as effective as Viokase and Cotazym, but at significantly lower enzyme doses.
Pancrease; Johnson & Johnson. Viokase; Viobin Corp. Cotazym; Organon, Inc.
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Khaw, K., Adeniyi-Jones, S., Gordon, D. et al. 444 EFFICACY OF PANCREATIN PREPARATIONS ON FAT AND NITROGEN AHSORPTIONS IN CYSTIC FIBROSIS PATIENTS. Pediatr Res 12 (Suppl 4), 437 (1978). https://doi.org/10.1203/00006450-197804001-00449
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DOI: https://doi.org/10.1203/00006450-197804001-00449