Abstract
Plasma DOC concentration and urinary excretion of tetrahydro-DOC (THDOC), free DOC and 18-OH-DOC, measured by specific radio-immunoassay, were similar in 7 children with essential hypertension and 4 patients with dexamethasone-suppressible hyperaldoste-ronism when compared with 5 normotensive controls (plasma DOC: 16.3±3.0 ng/dl, urinary excretion (μg/m2/24h) of THDOC: 23.5±5.0 free DOC: 0.1±0.01, free 18-OH-DOC: 0.8±0.2). There was no correlation between DOC and 18-OH-DOC levels and plasma renin activity, severity or type of hypertension. During a continuous 5-day ACTH infusion (40 U/24h) urinary 18-OH-DOC increased 20-50 fold in all groups. Plasma DOC concentration and urinary THDOC excretion increased 20 fold, and urinary free DOC rose 20-50 fold in the control group and in the children with essential hypertension. The highest increase of THDOC (50 fold) and free DOC (100 fold) after ACTH was seen in the children with dexamethasone-suppressible hyperaldosteronism. However neither the observed salt retention nor the rise in blood pressure after ACTH stimulation were correlated with DOC or 18-OH-DOC in any of the groups. The rise in blood pressure after ACTH was independent of changes in salt and water balance. Conclusions: 1) DOC and 18-OH-DOC do not appear to play a major role in most cases of juvenile hypertension. 2) The marked rise of DOC and 18-OH-DOC may contribute to the rise in blood pressure with ACTH. 3) The blood pressure elevation after ACTH cannot be solely attributed to salt retention resulting from an increase in DOC secretion.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rauh, W., Lustig, R., Gottesdiener, K. et al. 329 II-DESOXYCORTICOSTERONE (DOC) AND 18-HYDROXY-DOC(18-OH-DOC) IN JUVENILE HYPERTENSION. Pediatr Res 12 (Suppl 4), 418 (1978). https://doi.org/10.1203/00006450-197804001-00334
Issue Date:
DOI: https://doi.org/10.1203/00006450-197804001-00334