Abstract
Antibodies to thyroid cytoplasm (T.C.A.), to thyroid nuclei (ANA) and to thyroglobulin (T.G.A.) were determined in 30 children with thyrotoxicosis (Tx), in 13 with euthyroid goiter (EG), in 9 with hypothyroidism and goiter (H.G.) and in 6 with hypothyroidism with no goiter (H). Histocompatibility (HL-A) antigens were also studied. The results (as percentages) were:
Patients with Tx had increased HLA-B8 (45% of controls 25% p <0.05) whereas the other thyroid patients did not. Siblings, one with Tx and one with juvenile diabetes were HLA identical (B8+) whereas an unaffected sibling shared none of the types.
Families of Tx had increased Tx, rheumatoid arthritis and S.L.E. In summary, Tx is strongly inherited and related to HLA-B8. Patients with B8 have more T.G.A. and higher titers of T.C.A., but show less tendency to remit. We speculate that Tx is an antibody mediated disease and thyroiditis a predominantly cell mediated disorder. Supported by NIH grants AM19286 and AM05745.
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McLaughlin, J., Maclaren, N., Krupp, B. et al. 311 Thyroid Antibodies and HL-A Antigens in Children with Thyroid Disease. Pediatr Res 12 (Suppl 4), 415 (1978). https://doi.org/10.1203/00006450-197804001-00316
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DOI: https://doi.org/10.1203/00006450-197804001-00316