Abstract
Fifteen infants(gest.age 27 wks.and birthweight 847g)were given indomethacin in 1-3 doses(total 0.39mg/kg)for PDA, at median age of 7 days(range 4-66).Echocardiograms were performed before and after indo(mean 1.67 days).Eleven infants responded clinically (Gp 1) and 4 did not (Gp 2).Both groups had similar pre-indo echo values but Gp 2 did not change significantly after therapy.
Pre-indo findings suggest enhanced LV contraction with reduced afterload and increased preload. Gp 1 echo changes are similar to those after ductal ligation.This and the finding that Gp 2 shows no changes in LV echo measurements after indo suggest that the changes in Gp 1 are due to constriction of the ductus and not to myocardial depression. Unchanging RPEP/RVET in both groups is consistent with unaltered RV function and/or pulmonary vascular resistance with the doses of indo used.
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Halliday, H., Keroes, J., Hogg, D. et al. 117 CHANGES IN LEFT VENTRICULAR (LV) CONTRACTION AND PULMONARY VASCULAR RESISTANCE AFTER INDOMETHACIN FOR PATENT DUCTUS AFTERIOSUS (PDA). Pediatr Res 12 (Suppl 4), 383 (1978). https://doi.org/10.1203/00006450-197804001-00122
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DOI: https://doi.org/10.1203/00006450-197804001-00122