Abstract
The anaemia of protein-energy malnutrition (PEM) observed in Kivu is a distinct syndrome, characterized a.o. by a slight hemolysis and by surprisingly normal 2,3-DPG and P50 levels for age and altitude.
In an attempt to define the mechanisms of these phenomenons, the following parameters have been studied in large numbers of untreated, treated and healthy children : glycolytic rate, enzymatic activities (HK, PK, G6PO, 6PGD, GSSG-réd, GSH-Px and SOD), glycolytic metabolites, adenine nucleotides, glutathione, and Heinz body formation. The plasma and erythrocyte selenium levels were also determined.
It appears:
1) that there exists in PEM an erythrocyte glycolytic abnormality limiting the 2,3-DPG increase on hypoxia;
2) that the reduction of the activated oxygen is decreased because, firstly of a GSH-Px activity reduction attributable to a selenium deficiency, and secondly of decreased GSH levels.
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Fondu, P., Nève, J., Heyder-Bruckner, C. et al. ERYTHROCYTE METABOLISM IN PROTEIN-ENERGY MALNUTRITION ANAEMIA. I. GLUCOSE METABOLISM AND REDUCTION OF THE ACTIVATED OXYGEN. Pediatr Res 12, 65 (1978). https://doi.org/10.1203/00006450-197801000-00033
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DOI: https://doi.org/10.1203/00006450-197801000-00033