Abstract
Author's earlier studies /Péter and Szentistványi, 1977/ were continued in which a moderate rise of GH serum level was detected mainly at 150' and 180' after iv. bolus administration of somatostatin/SRIF/ in children. This rise is regular but the peak mean serum level is very low /8,05±3,02 ng/ml/. An iv. bolus of SRIF and p.o. 1-Dopa was administered in a combination for 16 normal children with the parental consent according to the following protocol: at 0 minute 5μg/ Kgbw SRIF and 120' later 250-500 mg 1-Dopa were given. The increase of GH level was significant at 150' and 180' /the peak mean serum level is 22,5±16,04 ng/ml; extreme values 9,7-57,5 ng/ml. The dose- and time relations are very important because the somatostatin can suppress the rise in serum GH evoked by 1-Dopa! By means of SRIF-1-Dopa loading test can help the differential diagnosis of dwarfism in a harmless form too.
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Péter, F. Somatostatin and 1-Dopa loading for study of Growth Hormone reserve. Pediatr Res 12, 1094 (1978). https://doi.org/10.1203/00006450-197811000-00078
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DOI: https://doi.org/10.1203/00006450-197811000-00078