Abstract
The majority of children with long-standing juvenile hypothyroidism show sexual maturation of characteristic pattern advanced in relation to bone age and mediated by FSH release (N.D. Barnes, A.B. Hayles, R.J. Ryan, Mayo Clin. Proc. 1973, 48, 849). The reason for the FSH release was obscure. We have studied the effect of an intravenous bolus of 200 μg TRH in 13 children (4 boys, 9 girls, age range 2.7 - 17.0 years) without thyroid disease. All showed a response in FSH as well as TSH but none a detectable response in LH. Three girls with primary hypothyroidism showed elevated resting levels of FSH and a further rise after TRH (see table).
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Barnes, N., Jones, J. & Grant, D. TRH releases FSH in children: an explanation for the elevated FSH levels in juvenile hypothyroidism. Pediatr Res 12, 155 (1978). https://doi.org/10.1203/00006450-197802000-00055
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DOI: https://doi.org/10.1203/00006450-197802000-00055