Abstract
Urine SG and Osm are tests commonly used in the evaluation of hydration in newborn infants. Pharmacologic studies in premature and term infants given routine IV doses of the penicillins show the following urine concentrations: Penicillin 25,000 units/kg/dose → 31-3000 μg/ml urine; Ampicillin 25-100 mg/kg/dose → 60-11,000 μg/ml; Methicillin 20 mg/kg/dose → 160-180 μg/ml; Carbenicillin 50-100 mg/kg/dose → 1399-2689 μg/ml. Serial dilutions of these antibiotics in urine were made to determine their effect on SG and Osm which were measured using a refractometer and by freezing point depression. Results [Antibiotic] μg/ml/urine
Similar results were obtained with Carbenicillin. Kanamycin and gentamycin had no effect on urine SG when tested in concentrations found in the urine after the usual IV dose. The results indicate that in infants receiving high doses of the penicillins the finding of an elevated urine SG and Osm should be interpreted with caution to prevent inappropriate fluid therapy.
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Marks, K., Friedman, Z. & Maisels, M. 1091 POSSIBLE EFFECT OF ANTIBIOTICS ON URINE SPECIFIC GRAVITY (SG) AND OSMOLALITY (Osm) IN THE NEWBORN. Pediatr Res 12 (Suppl 4), 545 (1978). https://doi.org/10.1203/00006450-197804001-01097
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DOI: https://doi.org/10.1203/00006450-197804001-01097