Abstract
This study was done to determine effect of salt-poor albumin on blood volume (BV) and renal function in ten premature infants (GA 28-36 weeks, body weight 1.43 ± 0.15 SE kg) with total serum protein (TSP) < 4.5 g/dl. They were given 1 g/kg albumin as 25% salt-poor solution iv in 5-10 min. Urine was obtained in a bag applied to the infant; the bladder was creded after each voiding and when collection periods ended. Initial BV was measured using Evan's blue; changes over a 40-min period were estimated from changes in hematocrit (Hct). Mean arterial blood pressure (MABP) was continuously monitored through an umbilical arterial catheter. Serum and urine osmolarities and creatinines, TSP, colloid osmotic pressure (COP), BV, and MABP were measured and creatinine clearance (CCr) calculated before and after albumin infusion. An increase in BV from 88 ± 5 to 100 ± 8 ml/kg (P<.0005) was first observed 10 min after infusion and then remained unchanged during the study; this was paralleled by increases in TSP from 4.4 ± 0.1 to 4.8 ± 0.1 g/dl (P<.0005) and COP from 20 ± 1 to 25 ± 1 cm H2O (P<.0005). However, MABP was not significantly changed. There was an increase in CCr from .42 ± .09 to .89 ± .17 ml/min (P< .0005), but CH2O and Uosm/Posm did not significantly change. Apparently, observed changes in MABP, BV, and Hct had a greater influence in increasing GFR than increases in COP had in decreasing it. In conclusion, albumin infusion may help improve GFR in hypoproteinemic premature infants.
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Lay, K., Bancalari, E., Malkus, H. et al. 1083 EFFECT OF ALBUMIN ADMINISTRATION ON RENAL FUNCTION IN PREMATURE INFANTS. Pediatr Res 12 (Suppl 4), 544 (1978). https://doi.org/10.1203/00006450-197804001-01089
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DOI: https://doi.org/10.1203/00006450-197804001-01089